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Beilstein-Institut, Beilstein Journal of Nanotechnology, (5), p. 1477-1490, 2014

DOI: 10.3762/bjnano.5.161

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In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

Journal article published in 2014 by Moritz Nazarenus, Qian Zhang, Mahmoud G. Soliman, Pablo del Pino ORCID, Beatriz Pelaz, Susana Carregal-Romero, Joanna Rejman, Barbara Rothen-Rutishauser, Martin J. D. Clift ORCID, Reinhard Zellner, G. Ulrich Nienhaus ORCID, G. Ulrich Nienhaus, James B. Delehanty, Igor L. Medintz, Wolfgang J. Parak ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The interfacing of colloidal nanoparticles with mammalian cells is now well into its second decade. In this review our goal is to highlight the more generally accepted concepts that we have gleaned from nearly twenty years of research. While details of these complex interactions strongly depend, amongst others, upon the specific properties of the nanoparticles used, the cell type, and their environmental conditions, a number of fundamental principles exist, which are outlined in this review. © 2014 Nazarenus et al; licensee Beilstein-Institut. License and terms: see end of document.