Estrogen receptor signaling in the ferutinin-induced osteoblastic differentiation of human amniotic fluid stem cells
Journal article published in 2016 by
M. Zavatti,
M. Guida,
T. Maraldi,
F. Beretti,
L. Bertoni 
,
Gb B. La Sala,
A. De Pol
,
Gb B. La Sala,
A. De Pol
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Abstract
Ferutinin is a diaucane sesquiterpene with a high estrogenic activity. Since ferutinin is able to enhance osteoblastic differentiation of human amniotic fluid stem cells (hAFSCs), the aim of this study was to evaluate the role of the estrogen receptors α (ERα) and G-protein coupled receptor 30 (GPR30) in ferutinin-mediated osteoblastic differentiation. Moreover, it was investigated if MEK/ERK and PI3K/Akt signaling pathways are involved in ferutinin-induced effects.