Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sims, Rebecca; van der Lee, Sven J.; Van Der Lee, S. J.; Naj, Adam C.; Bellenguez, Céline; Badarinarayan, Nandini; Jakobsdottir, Johanna; Kunkle, Brian W.; Boland, Anne; Raybould, Rachel; Bis, Joshua C.; Martin, Eden R.; Grenier-Boley, Benjamin; Kuzma, Amanda B.; Heilmann-Heimbach, Stefanie; Sleegers, Kristel; Chouraki, Vincent; Vronskaya, Maria; Ruiz, Agustin; Graham, Robert R.; Olaso, Robert; Noethen, Markus M.; Hoffmann, Per; Grove, Megan L.; Vardarajan, Badri N.; Nöthen, Markus M.; Hiltunen, Mikko; White, Charles C.; Hamilton-Nelson, Kara L.; Epelbaum, Jacques; Maier, Wolfgang; Choi, Seung-Hoan; Beecham, Gary W.; Smith, Albert V.; Dulary, Cécile; Herms, Stefan; Funk, Cory C.; Derbois, Céline; Li, Hongdong; Forstner, Andreas J.; Sanchez-Juan, Pascual; Satizabal, Claudia L.; Ahmad, Shahzad; Bacq, Delphine; Valladares, Otto; Squassina, Alessio; Harold, Denise; Thomas, Rhodri; Qu, Liming; Sánchez-Juan, Pascual; Brody, Jennifer A.; Morgan, Taniesha; Sanchez Garcia, Florentino; Wolters, Frank J.; Zhao, Yi; Denning, Nicola; Malamon, John; Naranjo, Maria Candida Deniz; Fornage, Myriam; Majounie, Elisa; Garcia, Florentino Sanchez; Deniz Naranjo, Maria Candida; Mosley, Thomas H.; Wallon, David; Dombroski, Beth; Lupton, Michelle K.; Dupuis, Josée; Whitehead, Patrice; Fratiglioni, Laura; Medway, Christopher; Mukherjee, Shubhabrata; Jian, Xueqiu; Keller, Lina; Brown, Kristelle; Lin, Honghuang; Panza, Francesco; Cantwell, Laura B.; McGuinness, Bernadette; Moreno-Grau, Sonia; Burgess, Jeremy D.; Solfrizzi, Vincenzo; Proitsi, Petra; Allen, Mariet; Seripa, Davide; Adams, Hieab H.; Pastor, Pau; Adrienne Cupples, L.; Cupples, L. Adrienne; Price, Nathan D.; Hannequin, Didier; Frank-García, Ana; Levy, Daniel; Chakrabarty, Paramita; Caffarra, Paolo; Giegling, Ina; Beiser, Alexa S.; Wang, Xue; Garcia, Melissa E.; Giedraitis, Vilmantas; Hampel, Harald; Lannfelt, Lars; Mecocci, Patrizia; Eiriksdottir, Gudny; Pasquier, Florence; Crane, Paul K.; Boccardi, Virginia; Scherer, Martin; Henández, Isabel; Barber, Robert C.; Tarraga, Lluis; Leber, Markus; Adams, Perrie M.; Chen, Yuning; Riedel-Heller, Steffi; Albert, Marilyn S.; Emilsson, Valur; Beekly, Duane; Schmidt, Reinhold; Braae, Anne; Masullo, Carlo; Blacker, Deborah; Schmidt, Helena; Spalletta, Gianfranco; Doody, Rachelle S.; Longstreth, W. T.; Fairchild, Thomas J.; Lopez, Oscar L.; Bossù, Paola; Sacchinelli, Eleonora; Frosch, Matthew P.; Yang, Qiong; Ghetti, Bernardino; Huebinger, Ryan M.; Li, Shuo; Kamboh, M. Ilyas; Jessen, Frank; Ilyas Kamboh, M.; Sotolongo-Grau, Oscar; Morris, John C.; Katz, Mindy J.; Corcoran, Chris; Dunstan, Melanie; Thomas, Charlene; Braddel, Amy; Meggy, Alun; Marshall, Rachel; Gerrish, Amy; Chapman, Jade; Taylor, Sarah; Diez Fairen, Mnica; Hill, Matt; Aguilar, Miquel; Vellas, Bruno; Soininen, Hilkka; Hodges, Angela; Kloszewska, Iwona; Fairén, Mònica Díez; Uphill, James; Daniilidou, Makrina; Patel, Yogen; Hughes, Joseph T.; Lord, Jenny; Turton, James; Hartmann, Annette M.; Cecchetti, Roberta; Serpente, Maria; Fenoglio, Chiara; Arcaro, Marina; Orfei, Maria Donata; Caltagirone, Carlo; Pichler, Sabrina; Forte, Juan; Ciaramella, Antonio; Mayhaus, Manuel; Gu, Wei; Lleó, Alberto; Blesa, Rafael; Barber, Imelda S.; Maletta, Raffaele Giovanni; Brookes, Keeley; Fortea, Juan; Cupidi, Chiara; Sorbi, Sandro; Carrell, David; Moebus, Susanne; Urbano, Maria; Pilotto, Alberto; Kornhuber, Johannes; Bosco, Paolo; Todd, Stephen; Jr, W. T. Longstreth; Craig, David; Johnston, Janet; Lawlor, Brian; Gill, Michael; Lynch, Aoibhinn; Fox, Nick C.; Hardy, John; Albin, Roger L.; Apostolova, Liana G.; Arnold, Steven E.; Asthana, Sanjay; Atwood, Craig S.; Baldwin, Clinton T.; Barnes, Lisa L.; Barral, Sandra; Beach, Thomas G.; Becker, James T.; Bigio, Eileen H.; Bird, Thomas D.; Boeve, Bradley F.; Bowen, James D.; Boxer, Adam; Burke, James R.; Burns, Jeffrey M.; Buxbaum, Joseph D.; Cairns, Nigel J.; Cao, Chuanhai; Carlson, Chris S.; Carlsson, Cynthia M.; Carney, Regina M.; Carrasquillo, Minerva M.; Carroll, Steven L.; Diaz, Carolina Ceballos; Chui, Helena C.; Clark, David G.; Cribbs, David H.; Crocco, Elizabeth A.; DeCarli, Charles; Dick, Malcolm; Duara, Ranjan; Evans, Denis A.; Faber, Kelley M.; Fallon, Kenneth B.; Fardo, David W.; Farlow, Martin R.; Ferris, Steven; Foroud, Tatiana M.; Galasko, Douglas R.; Gearing, Marla; Geschwind, Daniel H.; Gilbert, John R.; Graff-Radford, Neill R.; Green, Robert C.; Growdon, John H.; Karydas, Anna; Hamilton, Ronald L.; Kaye, Jeffrey A.; Harrell, Lindy E.; Kim, Ronald; Honig, Lawrence S.; Kowall, Neil W.; Huentelman, Matthew J.; Kramer, Joel H.; Hulette, Christine M.; LaFerla, Frank M.; Hyman, Bradley T.; Lah, James J.; Jarvik, Gail P.; Leverenz, James B.; Abner, Erin; Levey, Allan I.; Jin, Lee-Way; Li, Ge; Jun, Gyungah; Lieberman, Andrew P.; Lunetta, Kathryn L.; Lyketsos, Constantine G.; Marson, Daniel C.; Martiniuk, Frank; Mash, Deborah C.; Masliah, Eliezer; McCormick, Wayne C.; McCurry, Susan M.; McDavid, Andrew N.; McKee, Ann C.; Mesulam, Marsel; Miller, Bruce L.; Olichney, John M.; Miller, Carol A.; Miller, Joshua W.; Murrell, Jill R.; Myers, Amanda J.; O'Bryant, Sid; Pankratz, Vernon S.; Parisi, Joseph E.; Paulson, Henry L.; Raskind, Murray; Perry, William; Reisberg, Barry; Peskind, Elaine; Reitz, Christiane; Pierce, Aimee; Poon, Wayne W.; Ringman, John M.; Potter, Huntington; Roberson, Erik D.; Rogaeva, Ekaterina; Quinn, Joseph F.; Raj, Ashok; Rosen, Howard J.; Rosenberg, Roger N.; Sager, Mark A.; Saykin, Andrew J.; Schneider, Julie A.; Schneider, Lon S.; Seeley, William W.; Smith, Amanda G.; Sonnen, Joshua A.; Spina, Salvatore; Stern, Robert A.; Swerdlow, Russell H.; Tanzi, Rudolph E.; Thornton-Wells, Tricia A.; Wingo, Thomas S.; Trojanowski, John Q.; Troncoso, Juan C.; Van Deerlin, Vivianna M.; Van Eldik, Linda J.; Vinters, Harry V.; Vonsattel, Jean Paul; Weintraub, Sandra; Williamson, Jennifer; Welsh-Bohmer, Kathleen A.; Wilhelmsen, Kirk C.; Woltjer, Randall L.; Wright, Clinton B.; Yu, Chang-En; Yu, Lei; Garzia, Fabienne; Golamaully, Feroze; Septier, Gislain; Munoz Fernadez, Carmen; J., van der Lee Sven; Engelborghs, Sebastien; Vandenberghe, Rik; Aladro Benito, Yoland; De Deyn, Peter P.; Thonberg, Hakan; Fernadez, Carmen Muñoz; Lilius, Lena; Forsell, Charlotte; Kinhult-Stählbom, Anne; Benito, Yoland Aladro; Kilander, Lena; Brundin, RoseMarie; van Duijn, Cornelia M.; Concari, Letizia; Koivisto, Anne Maria; Helisalmi, Seppo; Haapasalo, Annakaisa; Dermecourt, Vincent; Fievet, Nathalie; Hanon, Olivier; Ritchie, Karen; Dufouil, Carole; Brice, Alexis; Keene, C. Dirk; Dubois, Bruno; Tschanz, JoAnn; Dirk Keene, C.; Himali, Jayanadra J.; Kukull, Walter A.; Norton, Maria; Fitzpatrick, Annette L.; Larson, Eric B.; C., Naj Adam; Rotter, Jerome I.; Aspelund, Thor; Munger, Ron; Lipton, Richard B.; Bullido, María J.; Hofman, Albert; Montine, Thomas J.; Coto, Eliecer; Petersen, Ronald C.; Rivadeneira, Fernando; Boerwinkle, Eric; Reiman, Eric M.; Alvarez, Victoria; Reisch, Joan S.; O'Donnell, Christopher J.; Gallo, Maura; Royall, Donald R.; Bruni, Amalia Cecilia; Sano, Mary; Dichgans, Martin; St George-Hyslop, Peter; Galimberti, Daniela; Tsolaki, Magda; Scarpini, Elio; Tsuang, Debby W.; Mancuso, Michelangelo; Winslow, Ashley R.; Bonuccelli, Ubaldo; Daniele, Antonio; Wu, Chuang-Kuo; Peters, Oliver; Nacmias, Benedetta; Riemenschneider, Matthias; Uitterlinden, Andre G.; Heun, Reinhard; Brayne, Carol; Rubinsztein, David C.; Bras, Jose; Guerreiro, Rita; Shaw, Christopher E.; Al-Chalabi, Ammar; Collinge, John; Mann, David; Sussams, Rebecca; Clarimón, Jordi; Lovestone, Simon; O'Donovan, Michael C.; Owen, Michael J.; Behrens, Timothy W.; Mead, Simon; Cruchaga, Carlos; Ingelsson, Martin; Holmes, Clive; Bennett, David A.; Powell, John; Golde, Todd E.; Graff, Caroline; Morgan, Kevin; Goate, Alison M.; De Jager, Philip L.; Ertekin-Taner, Nilufer; Psaty, Bruce M.; Younkin, Steven G.; Combarros, Onofre; Passmore, Peter; Berr, Claudine; Rujescu, Dan; Gudnason, Vilmundur; Dickson, Dennis W.; Destefano, A. L.; Dartigues, Jean-François; Ortega-Cubero, Sara; Hakonarson, Hakon; Campion, Dominique; Kauwe, John Keoni; DeStefano, Anita L.; Boada, Merce; Van Broeckhoven, Christine; Farrer, Lindsay A.; Van Duijn, C. M.; Ikram, M. Arfan; Tzourio, Christophe; Jones, Lesley; Arfan Ikram, M.; Haines, Jonathan L.; Launer, Lenore J.; Escott-Price, Valentina; Mayeux, Richard; Deleuze, Jean-François; Amin, Najaf; Pericak-Vance, Margaret A.; Holmans, Peter A.; Wang, Li-San; Amouyel, Philippe; Ramirez, Alfredo; Seshadri, Sudha; Lambert, Jean-Charles; ARUKConsortium,; Perades, Gerad; Williams, Julie; Charge,; Schellenberg, Gerard D.; Adgc,; Eadi,

Dissemin
Sven van der Lee
Sims et al., 2017

Published in

Nature Research, Nature Genetics, 9(49), p. 1373-1384

DOI: 10.1038/ng.3916

Tools

Export citation

Format

@article{Sims2017,
  author = {Sims, Rebecca and van der Lee, Sven J. and Van Der Lee, S. J. and Naj, Adam C. and Bellenguez, Céline and Badarinarayan, Nandini and Jakobsdottir, Johanna and Kunkle, Brian W. and Boland, Anne and Raybould, Rachel and Bis, Joshua C. and Martin, Eden R. and Grenier-Boley, Benjamin and Kuzma, Amanda B. and Heilmann-Heimbach, Stefanie and Sleegers, Kristel and Chouraki, Vincent and Vronskaya, Maria and Ruiz, Agustin and Graham, Robert R. and Olaso, Robert and Noethen, Markus M. and Hoffmann, Per and Grove, Megan L. and Vardarajan, Badri N. and Nöthen, Markus M. and Hiltunen, Mikko and White, Charles C. and Hamilton-Nelson, Kara L. and Epelbaum, Jacques and Maier, Wolfgang and Choi, Seung-Hoan and Beecham, Gary W. and Smith, Albert V. and Dulary, Cécile and Herms, Stefan and Funk, Cory C. and Derbois, Céline and Li, Hongdong and Forstner, Andreas J. and Sanchez-Juan, Pascual and Satizabal, Claudia L. and Ahmad, Shahzad and Bacq, Delphine and Valladares, Otto and Squassina, Alessio and Harold, Denise and Thomas, Rhodri and Qu, Liming and Sánchez-Juan, Pascual and Brody, Jennifer A. and Morgan, Taniesha and Sanchez Garcia, Florentino and Wolters, Frank J. and Zhao, Yi and Denning, Nicola and Malamon, John and Naranjo, Maria Candida Deniz and Fornage, Myriam and Majounie, Elisa and Garcia, Florentino Sanchez and Deniz Naranjo, Maria Candida and Mosley, Thomas H. and Wallon, David and Dombroski, Beth and Lupton, Michelle K. and Dupuis, Josée and Whitehead, Patrice and Fratiglioni, Laura and Medway, Christopher and Mukherjee, Shubhabrata and Jian, Xueqiu and Keller, Lina and Brown, Kristelle and Lin, Honghuang and Panza, Francesco and Cantwell, Laura B. and McGuinness, Bernadette and Moreno-Grau, Sonia and Burgess, Jeremy D. and Solfrizzi, Vincenzo and Proitsi, Petra and Allen, Mariet and Seripa, Davide and Adams, Hieab H. and Pastor, Pau and Adrienne Cupples, L. and Cupples, L. Adrienne and Price, Nathan D. and Hannequin, Didier and Frank-García, Ana and Levy, Daniel and Chakrabarty, Paramita and Caffarra, Paolo and Giegling, Ina and Beiser, Alexa S. and Wang, Xue and Garcia, Melissa E. and Giedraitis, Vilmantas and Hampel, Harald and Lannfelt, Lars and Mecocci, Patrizia and Eiriksdottir, Gudny and Pasquier, Florence and Crane, Paul K. and Boccardi, Virginia and Scherer, Martin and Henández, Isabel and Barber, Robert C. and Tarraga, Lluis and Leber, Markus and Adams, Perrie M. and Chen, Yuning and Riedel-Heller, Steffi and Albert, Marilyn S. and Emilsson, Valur and Beekly, Duane and Schmidt, Reinhold and Braae, Anne and Masullo, Carlo and Blacker, Deborah and Schmidt, Helena and Spalletta, Gianfranco and Doody, Rachelle S. and Longstreth, W. T. and Fairchild, Thomas J. and Lopez, Oscar L. and Bossù, Paola and Sacchinelli, Eleonora and Frosch, Matthew P. and Yang, Qiong and Ghetti, Bernardino and Huebinger, Ryan M. and Li, Shuo and Kamboh, M. Ilyas and Jessen, Frank and Ilyas Kamboh, M. and Sotolongo-Grau, Oscar and Morris, John C. and Katz, Mindy J. and Corcoran, Chris and Dunstan, Melanie and Thomas, Charlene and Braddel, Amy and Meggy, Alun and Marshall, Rachel and Gerrish, Amy and Chapman, Jade and Taylor, Sarah and Diez Fairen, Mnica and Hill, Matt and Aguilar, Miquel and Vellas, Bruno and Soininen, Hilkka and Hodges, Angela and Kloszewska, Iwona and Fairén, Mònica Díez and Uphill, James and Daniilidou, Makrina and Patel, Yogen and Hughes, Joseph T. and Lord, Jenny and Turton, James and Hartmann, Annette M. and Cecchetti, Roberta and Serpente, Maria and Fenoglio, Chiara and Arcaro, Marina and Orfei, Maria Donata and Caltagirone, Carlo and Pichler, Sabrina and Forte, Juan and Ciaramella, Antonio and Mayhaus, Manuel and Gu, Wei and Lleó, Alberto and Blesa, Rafael and Barber, Imelda S. and Maletta, Raffaele Giovanni and Brookes, Keeley and Fortea, Juan and Cupidi, Chiara and Sorbi, Sandro and Carrell, David and Moebus, Susanne and Urbano, Maria and Pilotto, Alberto and Kornhuber, Johannes and Bosco, Paolo and Todd, Stephen and Jr, W. T. Longstreth and Craig, David and Johnston, Janet and Lawlor, Brian and Gill, Michael and Lynch, Aoibhinn and Fox, Nick C. and Hardy, John and Albin, Roger L. and Apostolova, Liana G. and Arnold, Steven E. and Asthana, Sanjay and Atwood, Craig S. and Baldwin, Clinton T. and Barnes, Lisa L. and Barral, Sandra and Beach, Thomas G. and Becker, James T. and Bigio, Eileen H. and Bird, Thomas D. and Boeve, Bradley F. and Bowen, James D. and Boxer, Adam and Burke, James R. and Burns, Jeffrey M. and Buxbaum, Joseph D. and Cairns, Nigel J. and Cao, Chuanhai and Carlson, Chris S. and Carlsson, Cynthia M. and Carney, Regina M. and Carrasquillo, Minerva M. and Carroll, Steven L. and Diaz, Carolina Ceballos and Chui, Helena C. and Clark, David G. and Cribbs, David H. and Crocco, Elizabeth A. and DeCarli, Charles and Dick, Malcolm and Duara, Ranjan and Evans, Denis A. and Faber, Kelley M. and Fallon, Kenneth B. and Fardo, David W. and Farlow, Martin R. and Ferris, Steven and Foroud, Tatiana M. and Galasko, Douglas R. and Gearing, Marla and Geschwind, Daniel H. and Gilbert, John R. and Graff-Radford, Neill R. and Green, Robert C. and Growdon, John H. and Karydas, Anna and Hamilton, Ronald L. and Kaye, Jeffrey A. and Harrell, Lindy E. and Kim, Ronald and Honig, Lawrence S. and Kowall, Neil W. and Huentelman, Matthew J. and Kramer, Joel H. and Hulette, Christine M. and LaFerla, Frank M. and Hyman, Bradley T. and Lah, James J. and Jarvik, Gail P. and Leverenz, James B. and Abner, Erin and Levey, Allan I. and Jin, Lee-Way and Li, Ge and Jun, Gyungah and Lieberman, Andrew P. and Lunetta, Kathryn L. and Lyketsos, Constantine G. and Marson, Daniel C. and Martiniuk, Frank and Mash, Deborah C. and Masliah, Eliezer and McCormick, Wayne C. and McCurry, Susan M. and McDavid, Andrew N. and McKee, Ann C. and Mesulam, Marsel and Miller, Bruce L. and Olichney, John M. and Miller, Carol A. and Miller, Joshua W. and Murrell, Jill R. and Myers, Amanda J. and O'Bryant, Sid and Pankratz, Vernon S. and Parisi, Joseph E. and Paulson, Henry L. and Raskind, Murray and Perry, William and Reisberg, Barry and Peskind, Elaine and Reitz, Christiane and Pierce, Aimee and Poon, Wayne W. and Ringman, John M. and Potter, Huntington and Roberson, Erik D. and Rogaeva, Ekaterina and Quinn, Joseph F. and Raj, Ashok and Rosen, Howard J. and Rosenberg, Roger N. and Sager, Mark A. and Saykin, Andrew J. and Schneider, Julie A. and Schneider, Lon S. and Seeley, William W. and Smith, Amanda G. and Sonnen, Joshua A. and Spina, Salvatore and Stern, Robert A. and Swerdlow, Russell H. and Tanzi, Rudolph E. and Thornton-Wells, Tricia A. and Wingo, Thomas S. and Trojanowski, John Q. and Troncoso, Juan C. and Van Deerlin, Vivianna M. and Van Eldik, Linda J. and Vinters, Harry V. and Vonsattel, Jean Paul and Weintraub, Sandra and Williamson, Jennifer and Welsh-Bohmer, Kathleen A. and Wilhelmsen, Kirk C. and Woltjer, Randall L. and Wright, Clinton B. and Yu, Chang-En and Yu, Lei and Garzia, Fabienne and Golamaully, Feroze and Septier, Gislain and Munoz Fernadez, Carmen and J., van der Lee Sven and Engelborghs, Sebastien and Vandenberghe, Rik and Aladro Benito, Yoland and De Deyn, Peter P. and Thonberg, Hakan and Fernadez, Carmen Muñoz and Lilius, Lena and Forsell, Charlotte and Kinhult-Stählbom, Anne and Benito, Yoland Aladro and Kilander, Lena and Brundin, RoseMarie and van Duijn, Cornelia M. and Concari, Letizia and Koivisto, Anne Maria and Helisalmi, Seppo and Haapasalo, Annakaisa and Dermecourt, Vincent and Fievet, Nathalie and Hanon, Olivier and Ritchie, Karen and Dufouil, Carole and Brice, Alexis and Keene, C. Dirk and Dubois, Bruno and Tschanz, JoAnn and Dirk Keene, C. and Himali, Jayanadra J. and Kukull, Walter A. and Norton, Maria and Fitzpatrick, Annette L. and Larson, Eric B. and C., Naj Adam and Rotter, Jerome I. and Aspelund, Thor and Munger, Ron and Lipton, Richard B. and Bullido, María J. and Hofman, Albert and Montine, Thomas J. and Coto, Eliecer and Petersen, Ronald C. and Rivadeneira, Fernando and Boerwinkle, Eric and Reiman, Eric M. and Alvarez, Victoria and Reisch, Joan S. and O'Donnell, Christopher J. and Gallo, Maura and Royall, Donald R. and Bruni, Amalia Cecilia and Sano, Mary and Dichgans, Martin and St George-Hyslop, Peter and Galimberti, Daniela and Tsolaki, Magda and Scarpini, Elio and Tsuang, Debby W. and Mancuso, Michelangelo and Winslow, Ashley R. and Bonuccelli, Ubaldo and Daniele, Antonio and Wu, Chuang-Kuo and Peters, Oliver and Nacmias, Benedetta and Riemenschneider, Matthias and Uitterlinden, Andre G. and Heun, Reinhard and Brayne, Carol and Rubinsztein, David C. and Bras, Jose and Guerreiro, Rita and Shaw, Christopher E. and Al-Chalabi, Ammar and Collinge, John and Mann, David and Sussams, Rebecca and Clarimón, Jordi and Lovestone, Simon and O'Donovan, Michael C. and Owen, Michael J. and Behrens, Timothy W. and Mead, Simon and Cruchaga, Carlos and Ingelsson, Martin and Holmes, Clive and Bennett, David A. and Powell, John and Golde, Todd E. and Graff, Caroline and Morgan, Kevin and Goate, Alison M. and De Jager, Philip L. and Ertekin-Taner, Nilufer and Psaty, Bruce M. and Younkin, Steven G. and Combarros, Onofre and Passmore, Peter and Berr, Claudine and Rujescu, Dan and Gudnason, Vilmundur and Dickson, Dennis W. and Destefano, A. L. and Dartigues, Jean-François and Ortega-Cubero, Sara and Hakonarson, Hakon and Campion, Dominique and Kauwe, John Keoni and DeStefano, Anita L. and Boada, Merce and Van Broeckhoven, Christine and Farrer, Lindsay A. and Van Duijn, C. M. and Ikram, M. Arfan and Tzourio, Christophe and Jones, Lesley and Arfan Ikram, M. and Haines, Jonathan L. and Launer, Lenore J. and Escott-Price, Valentina and Mayeux, Richard and Deleuze, Jean-François and Amin, Najaf and Pericak-Vance, Margaret A. and Holmans, Peter A. and Wang, Li-San and Amouyel, Philippe and Ramirez, Alfredo and Seshadri, Sudha and Lambert, Jean-Charles and ARUKConsortium,  and Perades, Gerad and Williams, Julie and Charge,  and Schellenberg, Gerard D. and Adgc,  and Eadi, },
  doi = {10.1038/ng.3916},
  journal = {Nature Genetics},
  month = {jan},
  pages = {1373-1384},
  title = {Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease},
  url = {https://oadoi.org/10.1038/ng.3916},
  volume = {49},
  year = {2017}
}

Download

Export citation

Search in Google Scholar