Published in
Nature Research, Nature Genetics, 5(49), p. 674-679, 2017
DOI: 10.1038/ng.3821
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Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility
Journal article published in 2017 by
Daniel J. Wright 
,
Felix R. Day ,
Nicola D. Kerrison,
Florian Zink,
Alexia Cardona ,
Patrick Sulem,
Deborah J. Thompson ,
Svanhvit Sigurjonsdottir,
Daniel F. Gudbjartsson,
Agnar Helgason,
J. Ross Chapman ,
Steve P. Jackson,
Claudia Langenberg,
Nicholas J. Wareham,
Robert A. Scott
and other authors.
,
Felix R. Day ,
Nicola D. Kerrison,
Florian Zink,
Alexia Cardona ,
Patrick Sulem,
Deborah J. Thompson ,
Svanhvit Sigurjonsdottir,
Daniel F. Gudbjartsson,
Agnar Helgason,
J. Ross Chapman ,
Steve P. Jackson,
Claudia Langenberg,
Nicholas J. Wareham,
Robert A. Scott
and other authors.
This paper is made freely available by the publisher.
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Abstract
The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosomeY (mLOY), and its clinical relevance, are unknown. Using genotype array intensity data and sequence reads in 85,542 men, we identify 19 genomic regions (P