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Elsevier, Colloids and Surfaces B: Biointerfaces, (151), p. 34-38

DOI: 10.1016/j.colsurfb.2016.12.004

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Inverse hexagonal and cubic micellar lyotropic liquid crystalline phase behaviour of novel double chain sugar-based amphiphiles

Journal article published in 2017 by George C. Feast, Thomas Lepitre, Nhiem Tran, Charlotte E. Conn ORCID, Oliver E. Hutt ORCID, Xavier Mulet, Calum J. Drummond, G. Paul Savage
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The lyotropic phase behaviour of a library of sugar-based amphiphiles was investigated using high-throughput small-angle X-ray scattering (SAXS). Double unsaturated-chain monosaccharide amphiphiles formed inverse hexagonal and cubic micellar (Fd3m) lyotropic phases under excess water conditions. A galactose-oleyl amphiphile from the library was subsequently formulated into hexosome nanoparticles, which have potential uses as drug delivery vehicles. The nanoparticles were shown to be stable at elevated temperatures and non-cytotoxic up to at least 200 μg mL-1.