Published in

Wiley Open Access, CPT: Pharmacometrics and Systems Pharmacology, 2(6), p. 73-86, 2017

DOI: 10.1002/psp4.12155

Links

Tools

Export citation

Search in Google Scholar

The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions

Journal article published in 2017 by A. Lloret‐Villas, Tm Varusai ORCID, N. Juty, C. Laibe, N. Le NovÈre, H. Hermjakob, V. Chelliah
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current state of modeling in the area of neurodegeneration, and objectively compare the gaps between existing clinical knowledge and the mechanistic understanding of the major pathological processes implicated in neurodegenerative disorders. We also discuss new directions in the field of neurodegeneration that hold potential for furthering therapeutic interventions and strategies.