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American Association of Immunologists, The Journal of Immunology, 1_Supplement(198), p. 202.8-202.8, 2017

DOI: 10.4049/jimmunol.198.supp.202.8

Nature Research, Nature Communications, 1(8), 2017

DOI: 10.1038/ncomms14419

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Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

Journal article published in 2017 by Muhammad Myn Uddin, Ryo Motosugi, Izumi Ohigashi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki, Yasumasa Nishito, Immanuel Rode, Keiji Tanaka, Tatsuya Takemoto, Shigeo Murata ORCID, Yousuke Takahama ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractThe thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of β5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8+ T cells. A point mutation in this genome element results in a defect in β5t expression and CD8+ T-cell production in mice. The results reveal a Foxn1-β5t transcriptional axis that governs CD8+ T-cell production in the thymus.