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Nature Research, Nature Communications, 1(8), 2017

DOI: 10.1038/ncomms14318

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Cryptic bioactivity capacitated by synthetic hybrid plant peptides

Journal article published in 2017 by Yuki Hirakawa, Hidefumi Shinohara, Kai Welke, Stephan Irle ORCID, Yoshikatsu Matsubayashi, Keiko U. Torii ORCID, Naoyuki Uchida ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractEvolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling.