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American Society of Hematology, Blood, 2(129), p. e1-e12, 2017

DOI: 10.1182/blood-2016-05-714048

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Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

Journal article published in 2017 by Florian Beck, Jörg Geiger, Stepan Gambaryan, Fiorella A. Solari, Margherita Dell’Aica, Stefan Loroch, Nadine J. Mattheij, Igor Mindukshev, Oliver Pötz, Kerstin Jurk, Julia M. Burkhart, Christian Fufezan, Johan W. M. Heemskerk ORCID, Ulrich Walter, René P. Zahedi and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points Temporal profiles of >4000 phosphopeptides after stimulating human platelets (a) with ADP and (b) consecutively with ADP and Iloprost. Reciprocal phosphorylation profiles of ADP and Iloprost point to central players of platelet homeostasis.