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American Society for Cell Biology, Molecular Biology of the Cell, 25(27), p. 4043-4054

DOI: 10.1091/mbc.e16-08-0570

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Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex

Journal article published in 2016 by Evan L. Guiney, Till Klecker ORCID, Scott D. Emr
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Endocytosis of plasma membrane proteins in Saccharomyces cerevisiae requires their ubiquitination by the ART-Rsp5 ubiquitin ligase complex. Little is known about how the complex engages substrates. The Art1 C-terminus recognizes Mup1 via a tripartite ART sorting signal: an acidic patch, in proximity to the membrane and substrate lysines.