Dissemin is shutting down on January 1st, 2025

Published in

National Academy of Sciences, Proceedings of the National Academy of Sciences, 35(113), p. 9892-9897, 2016

DOI: 10.1073/pnas.1610078113

Links

Tools

Export citation

Search in Google Scholar

Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates

Journal article published in 2016 by Alvaro Duque, Zeljka Krsnik ORCID, Ivica Kostović, Pasko Rakic
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Green circle
Postprint: archiving allowed
Red circle
Published version: archiving forbidden
Data provided by SHERPA/RoMEO

Abstract

Significance The subplate zone, a transient cellular compartment of the embryonic cerebrum, has expanded in size and complexity during primate evolution, culminating in humans. Here, the application of multiple methods, including labeling time and place of neuronal origin and subsequent changes in their positions in macaque monkey embryos, and the use of histo- and immunochemistry in human fetal cerebral tissue of comparable prenatal ages reveals extraordinary cellular dynamics and unexpected secondary displacement of neurons. These findings may have significance for understanding cortical development and evolution and may provide insight into the pathogenesis of cortical disorders, as well as hypoxic-ischemic lesions in preterm infants.