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Mary Ann Liebert, Antioxidants and Redox Signaling, 6(27), p. 328-344

DOI: 10.1089/ars.2016.6643

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Oxidative Stress-Induced miR-200c Disrupts the Regulatory Loop Among SIRT1, FOXO1, and eNOS

Journal article published in 2017 by Fabrizio Carlomosti, Marco D'Agostino, Sara Beji, Alessio Torcinaro, Roberto Rizzi, Germana Zaccagnini, Biagina Maimone, Valeria Di Stefano, Francesca De Santa, Sonia Cordisco, Annalisa Antonini, Roberta Ciarapica, Elena Dellambra, Fabio Martelli, Daniele Avitabile and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Reactive oxygen species (ROS) play a pivotal role in different pathologic conditions, including ischemia, diabetes, and aging. We previously showed that ROS enhance miR-200c expression, causing endothelial cell (EC) apoptosis and senescence. Herein, we dissect the interaction among miR-200c and three strictly related proteins that modulate EC function and ROS production: sirtuin 1 (SIRT1), endothelial nitric oxide synthase (eNOS), and forkhead box O1 (FOXO1). Moreover, the role of miR-200c on ROS modulation was also investigated.