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Termedia Publishing, Journal of Contemporary Brachytherapy, (5), p. 434-437

DOI: 10.5114/jcb.2016.63461

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Successful treatment of a 67-year-old woman with urethral adenocarcinoma with the use of external beam radiotherapy and image guided adaptive interstitial brachytherapy

Journal article published in 2016 by Jasmin Mujkanovic, Mads Agerbæk ORCID, Kari Tanderup ORCID, Ulla Bisgaard, Søren Høyer, Jacob Christian Lindegaard, Lars Fokdal
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Primary urethral cancer (PUC) is a very rare disease. This case report illustrates a successful treatment approach of a 67-year-old woman with a urethral adenocarcinoma selected for an organ preserving treatment with external beam radiotherapy (EBRT) and interstitial brachytherapy (BT) boost, using the GEC-ESTRO target concept originally designed for locally advanced cervical cancer (LACC). Treatment included EBRT with 45 Gy in 25 fractions followed by image guided adaptive interstitial BT (IGABT) with a pulsed-dose-rate (PDR) BT boost with 30 Gy in 50 hourly pulses. The D90 for CTVHR was 79.1 Gy in EQD23. At 24 months follow-up, the patient was recurrence free and without treatment related side effects.