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Lippincott, Williams & Wilkins, PAIN, 3(158), p. 505-515, 2016

DOI: 10.1097/j.pain.0000000000000790

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Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain

Journal article published in 2016 by Camille Lagard, Lucie Chevillard, Karel Guillemyn, Patricia Risède, Jean-Louis Laplanche, Mariana Spetea, Steven Ballet, Bruno Mégarbane ORCID
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Abstract

KGNOP1, a mu-opioid receptor agonist/nociceptin receptor antagonist hybrid, can dually treat experimental neuropathic and nociceptive pain, more efficiently and safely than tramadol and morphine, respectively.