Dissemin is shutting down on January 1st, 2025

Published in

Mary Ann Liebert, Antioxidants and Redox Signaling, 5(26), p. 221-226, 2017

DOI: 10.1089/ars.2016.6845

Links

Tools

Export citation

Search in Google Scholar

Does furosemide increase oxidative stress in acute kidney injury?

Journal article published in 2017 by Benjamin I. Silbert ORCID, Kwok M. Ho ORCID, Jeffrey Lipman, Jason A. Roberts, Tomas B. Corcoran, Warren Pavey, David J. R. Morgan ORCID, Emilie Mas, Trevor A. Mori ORCID, Anne E. Barden
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Furosemide, a loop diuretic, is used to increase urine output in patients with acute kidney injury (AKI). It remains uncertain whether the benefits of furosemide in AKI outweigh its potential harms. We investigated if furosemide influenced oxidative stress in 30 critically ill patients with AKI by measuring changes in F2-isoprostanes (F2-IsoPs), markers of in vivo oxidative stress, in plasma and urine following intravenous furosemide. Urine F2-IsoPs were higher in sepsis (p = 0.001) and increased in proportion to urine furosemide (p = 0.001). The furosemide-induced increase in urine F2-IsoPs differed depending on AKI severity (p