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BioMed Central, Lipids in Health and Disease, 1(10), p. 146

DOI: 10.1186/1476-511x-10-146

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Response by sex to statin plus ezetimibe or statin monotherapy: A pooled analysis of 22,231 hyperlipidemic patients

Journal article published in 2011 by Beth L. Abramson, Pascale Benlian ORCID, Mary E. Hanson, Jianxin Lin, Arvind Shah, Andrew M. Tershakovec
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT: BACKGROUND: Despite documented benefits of lipid-lowering treatment in women, a considerable number are undertreated, and fewer achieve treatment targets vs. men. METHODS: Data were combined from 27 double-blind, active or placebo-controlled studies that randomized adult hypercholesterolemic patients to statin or statin+ezetimibe. Consistency of treatment effect among men (n=11,295) and women (n=10,499) was assessed and percent of men and women was calculated to evaluate the between-treatment ability to achieve specified treatment levels between sexes. RESULTS: Baseline lipids and hs-CRP were generally higher in women vs. men. Between-treatment differences were significant for both sexes (all p