Background Amphetamine use is a new critical health concern in the Middle East region. However, few studies have focused on methamphetamine use in this region, including Iran. Patients and Methods This cross-sectional study was conducted in 2010 to determine the prevalence of stimulant use among the general population of Tehran, the capital of Iran. A total of 6027 participants were recruited from 22 areas of Tehran and asked about their use of opioids and amphetamine. Results Of all participants, 261 (4.3%) had used methamphetamines (alone or with opiates) and 144 (2.4%) had used opiates only. Over 90% of participants were male and there was no difference between the two drug-using groups in terms of sex. The mean age of methamphetamine users (29 ± 9 years) was significantly lower than opioids users (36 ± 11 years, P