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BioMed Central, Chinese Journal of Cancer, p. 442-449

DOI: 10.5732/cjc.011.10040

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Mouse models of medulloblastoma

Journal article published in 2011 by Xiaochong Wu, Paul A. Northcott ORCID, Sidney Croul, Michael D. Taylor
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Medulloblastoma is the most common malignant pediatric brain tumor. Despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of human diseases, including cancer, and serve a valuable role as preclinical models for testing targeted therapies. In this review, we summarize how such models have been successfully applied to the study of medulloblastoma over the past decade and what we might expect in the coming years.