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MDPI, Nutrients, 3(9), p. 179

DOI: 10.3390/nu9020179

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Antiosteoporotic Activity of Genistein Aglycone in Postmenopausal Women: Evidence from a Post-Hoc Analysis of a Multicenter Randomized Controlled Trial

Journal article published in 2017 by Vincenzo Arcoraci ORCID, Marco Atteritano ORCID, Francesco Squadrito, Rosario D’Anna, Herbert Marini ORCID, Domenico Santoro ORCID, Letteria Minutoli, Sonia Messina, Domenica Altavilla, Alessandra Bitto
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Genistein has a preventive role against bone mass loss during menopause. However, experimental data in animal models of osteoporosis suggest an anti-osteoporotic potential for this isoflavone. We performed a post-hoc analysis of a previously published trial investigating the effects of genistein in postmenopausal women with low bone mineral density. The parent study was a randomized, double-blind, placebo-controlled trial involving postmenopausal women with a femoral neck (FN) density