Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Reviews Cancer, 4(17), p. 254-268, 2017

DOI: 10.1038/nrc.2016.140

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Interrogating open issues in cancer precision medicine with patient-derived xenografts

Journal article published in 2017 by Annette T. Byrne ORCID, Denis G. Alférez, Frédéric Amant, Daniela Annibali ORCID, Joaquín Arribas, Andrew V. Biankin, Alejandra Bruna, Eva Budinská, Carlos Caldas, David K. Chang, Robert B. Clarke, Hans Clevers, George Coukos, Virginie Dangles-Marie, S. Gail Eckhardt and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective of EurOPDX, an international initiative devoted to PDX-based research.