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Public Library of Science, PLoS ONE, 12(7), p. e50671, 2012

DOI: 10.1371/journal.pone.0050671

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Interaction between Maternal and Offspring Diet to Impair Vascular Function and Oxidative Balance in High Fat Fed Male Mice

Journal article published in 2012 by Christopher Torrens, Priya Ethirajan, Kimberley D. Bruce, Felino R. A. Cagampang ORCID, Richard C. M. Siow, Mark A. Hanson ORCID, Christopher D. Byrne ORCID, Giovanni E. Mann, Geraldine F. Clough
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Aims: to determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring. Methods: female C57BL6J mice were fed an obesogenic high fat diet (HF, 45% kcal fat) or standard chow (C, 21% kcal fat) pre-conception and throughout pregnancy and lactation. Post-weaning, male offspring were continued on the same diet as their mothers or placed on the alternative diet to give 4 dietary groups (C/C, HF/C, C/HF and HF/HF) which were studied at 15 or 30 weeks of age. Results: there were significant effects of maternal diet on offspring body weight (p