GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium

Matteini, Amy M. (Amy M.); Tanaka, Toshiko; Karasik, David; Atzmon, Gil; Chou, Wen-Chi; Eicher, John D. (John D.); Johnson, Andrew D. (Andrew); Arnold, Alice M. (Alice M.); Callisaya, Michele L.; Davies, Gail; Evans, Daniel S.; Evans, D. S. (Daniel); Holtfreter, Birte; Lohman, Kurt; Lunetta, Kathryn L. (Kathryn); Mangino, Massimo; Smith, Albert V. (Albert Vernon); Smith, Jennifer A. (Jennifer A); Teumer, Alexander; Yu, Lei; Arking, Dan E. (Dan); Buchman, Aron S. (Aron); Chibinik, Lori B. (Lori B.); De Jager, Philip L.; DeJager, P. L. (Philip L.); Evans, Denis A.; Evans, D. A. (Denis); Faul, Jessica D. (Jessica D.); Garcia, Melissa E.; Gillham-Nasenya, Irina; Gudnason, Vilmundur; Hofman, Albert; Hsu, Yi-Hsiang; Ittermann, Till; Lahousse, Lies; Liewald, David C. (David C.); Liu, Yongmei; Lopez, Lorna M. (Lorna); Rivadeneira, Fernando; Rotter, Jerome I. (Jerome I.); Siggeirsdottir, Kristin; Starr, John M. (John); Thomson, Russell; Tranah, Gregory J. (Gregory); Uitterlinden, André G. (André); Völker, Uwe; Völzke, Henry; Weir, David R. (David); Yaffe, Kristine; Zhao, Wei; Zhuang, Wei Vivian; Zmuda, Joseph M.; Bennett, David A. (David A.); Cummings, Steven R.; Deary, Ian J. (Ian J.); Ferrucci, Luigi; Harris, Tamara B. (Tamara); Kardia, Sharon Lr R. (Sharon); Kocher, Thomas; Kritchevsky, Stephen B. (Stephen); Psaty, Bruce M. (Bruce); Seshadri, Sudha; Spector, Timothy D. (Timothy); Srikanth, Velandai K.; Windham, B. Gwen; Zillikens, M. Carola; Newman, Anne B. (Anne B.); Walston, Jeremy D.; Kiel, Douglas P. (Douglas P.); Murabito, Joanne M.

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Wiley Open Access, Aging Cell, 5(15), p. 792-800, 2016

DOI: 10.1111/acel.12468

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GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium

Journal article published in 2016 by Amy M. (Amy M.) Matteini, Toshiko Tanaka, David Karasik, Gil Atzmon, Wen-Chi Chou, John D. (John D.) Eicher, Andrew D. (Andrew) Johnson, Alice M. (Alice M.) Arnold, Michele L. Callisaya, Gail Davies, Daniel S. Evans, D. S. (Daniel) Evans, Birte Holtfreter, Kurt Lohman, Kathryn L. (Kathryn) Lunetta

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Abstract

Decline in muscle strength with aging is an important predictor of health trajectory in the elderly. Several factors, including genetics, are proposed contributors to variability in muscle strength. To identify genetic contributors to muscle strength, a meta-analysis of genomewide association studies of handgrip was conducted. Grip strength was measured using a handheld dynamometer in 27581 individuals of European descent over 65years of age from 14 cohort studies. Genomewide association analysis was conducted on similar to 2.7 million imputed and genotyped variants (SNPs). Replication of the most significant findings was conducted using data from 6393 individuals from three cohorts. GWAS of lower body strength was also characterized in a subset of cohorts. Two genomewide significant (P-value

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GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium

Abstract