Two jet-stirred reactors (JSRs) coupled to gas chromatographic and spectroscopic techniques have been utilized to detect chemical species evolved during n-pentane oxidation at 1 and 10 atm, in the temperature range 500–1100 K, and at equivalence ratios of 0.3–2.0. To the authors' knowledge, this is the first study of a fuel's oxidation in two JSRs. In addition, the choice of experimental conditions results in there being the same concentration of n-pentane in all investigated mixtures; 1% at 1 atm, and 0.1% at 10 atm. This permits the additional assessment of the importance of pressure-dependent kinetics in predicting species concentration profiles. A recently published literature model Bugler et al. (2016) served as the starting point in simulating these experiments, with only minor additions and modifications necessary to achieve good overall agreement. The main adjustments were made to account for multi-oxygenated species (C5 aldehydes, ketones, diones, etc.) detected mainly at low temperatures (