Published in

Nature Research, Nature Reviews Immunology, 8(16), p. 469-484, 2016

DOI: 10.1038/nri.2016.62

Links

Tools

Export citation

Search in Google Scholar

The unfolded protein response in immunity and inflammation

Journal article published in 2016 by Joep Grootjans ORCID, Arthur Kaser, Randal J. Kaufman, Richard S. Blumberg
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands associated with environmental forces. In this role, the UPR has increasingly been shown to have crucial functions in immunity and inflammation. In this Review, we discuss the importance of the UPR in the development, differentiation, function and survival of immune cells in meeting the needs of an immune response. In addition, we review current insights into how the UPR is involved in complex chronic inflammatory diseases and, through its role in immune regulation, antitumour responses.