Dissemin is shutting down on January 1st, 2025

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Taylor and Francis Group, OncoImmunology, 1(6), p. e1256527

DOI: 10.1080/2162402x.2016.1256527

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Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles

Journal article published in 2016 by Elias J. Sayour, Gabriel De Leon, Christina Pham, Adam Grippin, Hanna Kemeny, Joshua Chua, Jianping Huang, John H. Sampson ORCID, Luis Sanchez-Perez, Catherine Flores, Duane A. Mitchell
This paper is available in a repository.
This paper is available in a repository.

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Abstract

While RNA-pulsed dendritic cell (DC) vaccines have shown promise, the advancement of cellular therapeutics is fraught with developmental challenges. To circumvent the challenges of cellular immunotherapeutics, we developed clinically translatable nanoliposomes that can be combined with tumor-derived RNA to generate personalized tumor RNA-nanoparticles (NPs) with considerable scale-up capacity. RNA-NPs bypass MHC restriction, are amenable to central distribution, and can provide near immediate immune induction.