Background: The pathways between serum uric acid (UA) levels and future cardiovascular events remain unclear. We studied the contributions of conventional risk factors, hemodynamics, and renal function to the relationship between UA and cardiovascular mortality among generally healthy treatment naïve adults. Methods: A cohort of 624 normotensive and 633 untreated hypertensive Taiwanese participants (overall 669 men, aged 30–79 years) with complete demographic, cardiovascular, and biochemistry studies was drawn from a community-based survey. Fatal cardiovascular events within 20 years' follow-up (n=90) were ascertained with National Death Registry database. Results: UA correlated significantly with brachial systolic blood pressure (SBP) (r = 0.240, P