Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Seow, W. J.; Shiraishi, K.; Song, M.; Wong, M. P.; NamKim, H.; Wang, Z.; Dean Hosgood, H.; Wang, J.-C.; Tucker, M.; Wei, H.; Zheng, W.; Zhou, B.; Shin, M.-H.; Wong, J. Y.; Kim, J. H.; Wang, P.; Zheng, H.; Yatabe, Y.; Zhang, X.-C.; Shu, X.-O.; Kim, Y. T.; Kim, Y.-C.; Tsuta, K.; Watanabe, S.-I.; Matsuo, K.; Man Ho, J. C.; Hsiung, C. A.; Tsuboi, M.; Yin, Z.; Shi, J.; Hong, Y.-C.; Takahashi, A.; Shimizu, K.; Chang, I.-S.; Tanaka, K.; Chatterjee, N.; Wu, T.; Wei, F.; Mitsudomi, T.; Sihoe, A. D.; Su, J.; Caporaso, N. E.; Song, F.; Albanes, D.; Su, W.-C.; Chung, L. P.; An, S.-J.; Yang, P.-C.; Xiang, Y.-B.; Bassig, B. A.; Chang, J.; Wu, C.; Ji, B.-T.; Kubo, M.; Daigo, Y.; Sung, J. S.; Wong, J. Y. Y.; Ito, H.; Tsai, Y.-H.; Momozawa, Y.; Ashikawa, K.; Kim, Y. H.; Wang, W.-C.; Kamatani, Y.; Honda, T.; Sakamoto, H.; Kim, H. N.; Yeager, M.; Kunitoh, H.; Hosgood, H. D. 3rd; Nokihara, H.; Wu, W.; Miyagi, Y.; Wang, J.; Nakayama, H.; Matsumoto, S.; Sung, S. W.; Goto, K.; Yang, T.-Y.; Goto, A.; Xu, J.; Minamiya, Y.; Kim, Y. C.; Tan, W.; Wang, C.-L.; Matsuda, F.; Ho, J. C.; Oh, I.-J.; Yoon, H.-I.; Lee, V. H. F.; Xu, P.; Chen, Y.-M.; Chang, G.-C.; Chen, K.-Y.; Huang, M.-S.; Vermeulen, R.; Wu, J.; Lin, H.-C.; Seow, A.; Park, J. Y.; Kweon, S.-S.; Yu, C.-J.; Chen, C.-J.; Li, H.; Gao, Y.-T.; Yamaji, T.; Qian, B.; Yang, Y.; Lu, D.; Liu, J.; Wyatt, K.; Jeon, H.-S.; Hsiao, C.-F.; Song, B.; Jung, Y. J.; Guo, H.; Hu, Z.; Liu, L.; Shimazu, T.; Chung, C. C.; Tsugane, S.; Lawrence, C.; Zhu, J.; Burdett, L.; Jacobs, K. B.; Wu, G.; Hutchinson, A.; Berndt, S. I.; Su, Y.-C.; He, X.; Tsai, F.-Y.; Yu, J.; Li, Y.; Loon Sihoe, A. D.; Stevens, V. L.; Choi, J. E.; Park, K. H.; Wu, Y.-L.; Kim, J. S.; Kang, C. H.; Shen, H.; Hu, L.; Chen, C.-H.; Guan, P.; Chen, Y.; Choi, Y. Y.; Hung, J.-Y.; Cai, Q.; Lin, C.-C.; Park, I. K.; Dong, J.; Kim, C.; He, Q.; Perng, R.-P.; Chen, C.-Y.; Lim, W.-Y.; Chen, K.-C.; Chan, J. K.; Chu, M.; Li, Y.-J.; Li, J.; Chen, H.; Jin, L.; Lo, Y.-L.; Chen, Y.-H.; Fraumeni, J. F.; Hicks, B.; Li, S. A.; Dai, J.; Ma, H.; Jin, G.; Cheng, S.; Li, X.; Ren, Y.; Cui, P.; Iwasaki, M.; Jiang, G.; Fei, K.; Chien, L.-H.; Chen, H.-L.; Chen, Y.-S.; Laird-Offringa, I. A.; Marconett, C. N.; Lin, D.; Chen, K.; Landi, M. T.; Rothman, N.; Kohno, T.; Chanock, S. J.; Lan, Q.; Seow, WJ;Matsuo K;Hsiung CA;Shiraishi K;Song M;Kim HN;Wong MP;Hong YC;Dean Hosgood H 3rd;Wang Z;Chang IS;Ping Chung L;An SJ;Wang P;Zheng H;Yatabe Y;Zhang XC;Kim YT;Shu XO;Kim YC;Bassig BA;Chang J;Ho JC;J

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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Journal article published in 2016 by W. J. Seow, K. Shiraishi, M. Song, M. P. Wong, H. NamKim, Z. Wang, H. Dean Hosgood, J.-C. Wang, M. Tucker, H. Wei, W. Zheng, B. Zhou, M.-H. Shin, J. Y. Wong, J. H. Kim and other authors.

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Abstract

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P