The objective of this academic work is to present the evidences available in literature about the relation between physical activity and sleep in regards to individuals living with HIV/AIDS. The databases: Web of Science, PubMed/MEDLINE, Science direct, Bireme, Scopus and EBSCO, were used to identify four articles, published until September 2015 to be included in this systematic review. According to the analyzed studies, interventions with physical activity for persons living with HIV/AIDS were significantly associated with the quality of sleep, total sleep time, efficiency, decreased of number of awakenings during sleep and improvement of sleeping disorders (insomnia). Therefore, the results presented in this research paper makes evident that physical activity has a relation with the quality of sleep amongst this specific population group, causing benefits to the quality of life of the patients. Nonetheless, it has been noticed that there is a necessity for more research and investigation in regards to the topic presented.