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American Society for Microbiology, Infection and Immunity, 11(72), p. 6324-6329, 2004

DOI: 10.1128/iai.72.11.6324-6329.2004

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RNA Encoding the MPT83 Antigen Induces Protective Immune Responses against Mycobacterium tuberculosis Infection

Journal article published in 2004 by Tian Xue, Evangelos Stavropoulos, Min Yang, Silvia Ragno, Martin Vordermeier, Mark Chambers ORCID, Glyn Hewinson, Douglas Bruce Lowrie, M. Joseph Colston, M. Joseph Colston, Ricardo E. Tascon
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We have previously demonstrated that vaccination of mice with plasmid DNA vectors expressing immunodominant mycobacterial genes induced cellular immune responses and significant protection against challenge with Mycobacterium tuberculosis . We demonstrate here, using in vitro-synthesized RNA, that vaccination with DNA or RNA constructs expressing the M. tuberculosis MPT83 antigen are capable of inducing specific humoral and T-cell immune responses and confer modest but significant protection against M. tuberculosis challenge in mice. This is the first report of protective immunity conferred against intracellular bacteria by an RNA vaccine. This novel approach avoids some of the drawbacks of DNA vaccines and illustrates the potential for developing new antimycobacterial immunization strategies.