This chapter is concerned with the potential of serious games as effective and engaging learning resources for people with learning and sensory disabilities. This is considered, followed by detailing of a suitable design methodology and its application, description of a range of types of games that have been successfully developed for this target group, and an explication of accessibility guidelines. Future development in this area is discussed, and it is concluded that there is great potential in the wide range of possible areas of research into, and development of, serious games for supporting people with learning and sensory disabilities, which would contribute greatly to their inclusion in society.