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Nature Research, Nature Communications, 1(5), 2014

DOI: 10.1038/ncomms4856

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A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus

Journal article published in 2014 by W. Cozen, Mn N. Timofeeva, D. Li, A. Diepstra ORCID, D. Hazelett, M. Delahaye-Sourdeix, Ck K. Edlund, L. Franke ORCID, Klaus Rostgaard ORCID, Dj J. Van Den Berg, Vk K. Cortessis ORCID, Ke E. Smedby, Sl L. Glaser, Westra H.-J., Ll L. Robison and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Recent genome wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio [OR] = 0.81, 95% confidence interval [95% CI] = 0.76–0.86, Pcombined = 3.5 × 10−10), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16.1, 5q31, 6p31.2, 8q24.21 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk