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Springer Nature [academic journals on nature.com], British Journal of Cancer, 6(100), p. 1014-1014, 2009

DOI: 10.1038/sj.bjc.6604992

Springer Nature [academic journals on nature.com], British Journal of Cancer, 2(100), p. 311-314, 2009

DOI: 10.1038/sj.bjc.6604858

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Direct effects of doxorubicin on skeletal muscle contribute to fatigue

Journal article published in 2009 by K. van Norren, A. van Helvoort ORCID, J. M. Argilés, S. van Tuijl, Karin Arts, M. Gorselink, A. Laviano, D. Kegler, H. P. Haagsman, E. M. van der Beek
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Chemotherapy-induced fatigue is a multidimensional symptom. Oxidative stress has been proposed as a working mechanism for anthracycline-induced cardiotoxicity. In this study, doxorubicin (DOX) was tested on skeletal muscle function. Doxorubicin induced impaired ex vivo skeletal muscle relaxation followed in time by contraction impediment, which could be explained by DOX-induced changes in Ca(2+) responses of myotubes in vitro. The Ca(2+) responses in skeletal muscle, however, could not be explained by oxidative stress.