Published in

Springer Nature [academic journals on nature.com], British Journal of Cancer, 2(100), p. 228-232, 2008

DOI: 10.1038/sj.bjc.6604801

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The spliceosome as target for anticancer treatment

Journal article published in 2008 by R. J. van Alphen, E. A. C. Wiemer ORCID, H. Burger, F. A. L. M. Eskens
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues.