Published in
Future Medicine, Future Oncology, 1(12), p. 59-70, 2016
DOI: 10.2217/fon.15.273
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Impact ofEGFRmutations andKRASamino acid substitution on the response to radiotherapy for brain metastasis of non-small-cell lung cancer
,
Nicolas Meyer,
Bertrand Mennecier,
Elisabeth Quoix,
Pierre-Emmanuel Falcoz,
Dominique Guénot,
Gilbert Massard,
Georges Noël,
Michèle Beau-Faller
Full text: Unavailable
Abstract
Background: Our study aimed to evaluate response rate (RR) to brain metastasis radiotherapy (RT), depending on the genomic status of non-small-cell lung cancer. Material & methods: We retrospectively reviewed 1971 non-small-cell lung cancer files of patients with EGFR and KRAS testing and focused on 157 patients who had undergone RT for brain metastasis. Results: A total of 16 patients (10.2%) harbored EGFR mutations (mEGFR) and 45 patients (28.7%) KRAS (mKRAS). In univariate analysis, RR was significantly higher for mEGFR compared with wild-type EGFR/KRAS (odds ratio [OR]: 4.96; p = 0.05) or mKRAS (OR: 1.81; p = 0.03). In multivariate analysis, KRAS G12V or G12C status was associated with both poor RR (OR: 0.1; p < 0.0001) and overall survival (OR: 3.41; p < 0.0001). Conclusion: mEGFR are associated with higher RR to brain RT than wild-type EGFR/RAS or mKRAS.