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American Chemical Society, Journal of the American Chemical Society, 38(133), p. 14975-14977, 2011

DOI: 10.1021/ja206742m

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Enhanced Mechanical Rigidity of Hydrogels Formed From Enantiomeric Peptide Assemblies

Journal article published in 2011 by Katelyn J. Nagy, Michael C. Giano, Albert Jin ORCID, Darrin J. Pochan, Joel P. Schneider
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Chirality can be used as a design tool to control the mechanical rigidity of hydrogels formed from self-assembling peptides. Hydrogels prepared from enantiomeric mixtures of self-assembling β-hairpins show non-additive, synergistic, enhancement in material rigidity compared to gels prepared from either pure enantiomer, with the racemic hydrogel showing the greatest effect. CD spectroscopy, TEM, and AFM indicate that this enhancement is defined by nanoscale interactions between enantiomers in the self-assembled state.