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Taylor and Francis Group, Scandinavian Journal of Gastroenterology, 5(32), p. 473-477, 1997

DOI: 10.3109/00365529709025084

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The release of gastric inhibitory peptide, glucagon-like peptide-I, and insulin after oral glucose test in colectomized subjects

Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

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Abstract

BACKGROUND: The physiologic role of the colon as an endocrine organ is not clear. We therefore studied the enteroinsular axis in patients with ulcerative colitis after colectomy. METHODS: The subjects included 11 patients with a conventional ileostomy, 10 patients with an ileoanal reservoir, and 10 normal controls. The concentrations of glucose, insulin, gastric inhibitory peptide (GIP), and glucagon-like peptide-I (GLP-I) were measured in plasma during an oral glucose test. RESULTS: The peak level of glucose and peak levels and area under the curve (AUC) of insulin and GIP were higher in patients (P