Published in
American Society of Hematology, Blood, 11(124), p. 1790-1798, 2014
DOI: 10.1182/blood-2014-04-567057
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- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Genetic alterations of the cohesin complex genes in myeloid malignancies
Journal article published in 2014 by
Swapna Thota,
Aaron D. Viny 
,
Hideki Makishima,
Barbara Spitzer,
Tomas Radivoyevitch ,
Bartlomiej Przychodzen,
Mikkael A. Sekeres,
Ross L. Levine ,
Jaroslaw P. Maciejewski
,
Hideki Makishima,
Barbara Spitzer,
Tomas Radivoyevitch ,
Bartlomiej Przychodzen,
Mikkael A. Sekeres,
Ross L. Levine ,
Jaroslaw P. Maciejewski
This paper is made freely available by the publisher.
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Abstract
Key Points Recurrent hypomorphic cohesin defects and cohesin low expression were identified in a significant proportion of patients with MDS and AML. Cohesin mutations likely represent secondary events in clonal hierarchy and contribute to clonal transformation.