Published in

Wiley, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 3(6), p. 271-278, 2014

DOI: 10.1002/wsbm.1265

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Signaling networks in palate development: Signaling in palate development

Journal article published in 2014 by Jamie Lane, Vesa Kaartinen ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Palatogenesis, the formation of the palate, is a dynamic process that is regulated by a complex series of context-dependent morphogenetic signaling events. Many genes involved in palatogenesis have been discovered through the use of genetically-manipulated mouse models as well as from human genetic studies, but the roles of these genes and their products in signaling networks regulating palatogenesis are still poorly known. In this review, we give a brief overview on palatogenesis and introduce key signaling cascades leading to formation of the intact palate. Moreover, we review conceptual differences between pathway biology and network biology and discuss how some of the recent technological advances in conjunction with mouse genetic models have contributed to our understanding of signaling networks regulating palate growth and fusion.