Elsevier, Journal of Biological Chemistry, 48(283), p. 33276-33286, 2008
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The B chain of ricin was expressed and delivered to the endoplasmic reticulum of tobacco protoplasts where it disappeared with time in a manner consistent with degradation. This turnover did not occur in the vacuoles or upon secretion. Indeed, several lines of evidence indicate that, in contrast to the turnover of endoplasmic reticulum-targeted ricin A chain in the cytosol, the bulk of expressed ricin B chain was degraded in the secretory pathway. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc.