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Elsevier, Journal of Biological Chemistry, 48(283), p. 33276-33286, 2008

DOI: 10.1074/jbc.m805222200

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Ricin B Chain Targeted to the Endoplasmic Reticulum of Tobacco Protoplasts Is Degraded by a CDC48- and Vacuole-independent Mechanism*

Journal article published in 2008 by Kerry L. Chamberlain, Richard S. Marshall, Nicholas A. Jolliffe, Lorenzo Frigerio ORCID, Aldo Ceriotti, J. Michael Lord, J. Michael Lord, Mike (J Mike) Lord, Lynne M. Roberts
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The B chain of ricin was expressed and delivered to the endoplasmic reticulum of tobacco protoplasts where it disappeared with time in a manner consistent with degradation. This turnover did not occur in the vacuoles or upon secretion. Indeed, several lines of evidence indicate that, in contrast to the turnover of endoplasmic reticulum-targeted ricin A chain in the cytosol, the bulk of expressed ricin B chain was degraded in the secretory pathway. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc.