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Elsevier, Bioorganic and Medicinal Chemistry, 6(17), p. 2175-2180, 2009

DOI: 10.1016/j.bmc.2008.10.075

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Discovery and Development of the Anticancer Agent Salinosporamide A (NPI-0052)

Journal article published in 2008 by William Fenical ORCID, Paul R. Jensen, Michael A. Palladino, Kin S. Lam, G. Kenneth Lloyd, G. Kenneth Lloyd, Barbara C. Potts
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The discovery of the anticancer agent salinosporamide A (NPI-0052) resulted from the exploration of new marine environments and a commitment to the potential of the ocean to yield new natural products for drug discovery and development. Driving the success of this process was the linkage of academic research together with the ability and commitment of industry to undertake drug development and provide the resources and expertise to advance the entry of salinosporamide A (NPI-0052) into human clinical trials. This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule.