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American Society for Microbiology, Journal of Virology, 14(87), p. 8235-8240, 2013

DOI: 10.1128/jvi.01085-13

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Induction of Cross-Reactive Antibodies to Novel H7N9 Influenza Virus by Recombinant Newcastle Disease Virus Expressing a North American Lineage H7 Subtype Hemagglutinin

Journal article published in 2013 by Peter H. Goff ORCID, Florian Krammer ORCID, Rong Hai, Christopher W. Seibert, Irina Margine, Adolfo García-Sastre, Peter Palese
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Severe human disease caused by the emerging H7N9 influenza virus in China warrants a rapid response. Here, we present a recombinant Newcastle disease virus expressing a North American lineage H7 influenza virus hemagglutinin. Sera from immunized mice were cross-reactive to a broad range of H7 subtype viruses and inhibited hemagglutination by the novel H7 hemagglutinin. Immunized mice were protected against a heterologous H7 subtype challenge, and genetic analysis suggested that cross-protective antibodies recognize conserved antigenic sites.