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Frontiers Media, Frontiers in Neurology, (5), 2014

DOI: 10.3389/fneur.2014.00222

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Identification of Pre-Spike Network in Patients with Mesial Temporal Lobe Epilepsy

Journal article published in 2014 by Nahla L. Faizo, Hana Burianová, Hana Burianová, Marcus Gray, Julia Hocking, Graham Galloway ORCID, David Reutens ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Seizures and interictal spikes in mesial temporal lobe epilepsy (MTLE) affect a network of brain regions rather than a single epileptic focus. Simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) studies have demonstrated a functional network in which hemodynamic changes are time-locked to spikes. However, whether this reflects the propagation of neuronal activity from a focus, or conversely the activation of a network linked to spike generation remains unknown. The functional connectivity (FC) changes prior to spikes may provide information about the connectivity changes that lead to the generation of spikes. We used EEG-fMRI to investigate FC changes immediately prior to the appearance of interictal spikes on EEG in patients with MTLE.