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Hindawi, Canadian Journal of Infectious Diseases and Medical Microbiology, 5(25), p. 271-276

DOI: 10.1155/2014/214813

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Serum voriconazole level variability in patients with hematological malignancies receiving voriconazole therapy

Journal article published in 2014 by Lalit Saini, Jack T. Seki, Seki Jt, Deepali Kumar, Eshetu G. Atenafu ORCID, Betty Yl L. Wong, Atenafu Eg, David Ec C. Cole, Cole De, Wong By, Andrea Božović, Joseph M. Brandwein, Brandwein Jm
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Voriconazole is an important antifungal agent used to treat invasive fungal infections; however, its administration can be difficult because of the narrow range between the level required for therapeutic efficacy and the level at which there is risk for hepatic and neurological toxicity. The purpose of this study was to elucidate the relationships among oral dosage, voriconazole levels and liver enzyme levels among leukemia patients.