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MDPI, Marine Drugs, 10(12), p. 5316-5327, 2014

DOI: 10.3390/md12105316

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Sinulolides A–H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp.

Journal article published in 2014 by Bin Yang, Xiaoyi Wei, Jingxia Huang, Xiuping Lin, Xuefeng Zhou, Juan Liu, Lishu Wang, Shengrong Liao ORCID, Junfeng Wang ORCID, Yonghong Liu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Eight new compounds, sinulolides A–H (1–8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-κB activation.