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American Association of Immunologists, The Journal of Immunology, 8(185), p. 4625-4632, 2010

DOI: 10.4049/jimmunol.1001480

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CD8 Controls T Cell Cross-Reactivity

Journal article published in 2010 by Linda Wooldridge, Bruno Laugel, Julia Ekeruche, Mathew Clement, Hugo A. van den Berg, David A. Price, Andrew K. Sewell ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Estimates of human αβ TCR diversity suggest that there are <108 different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered. Consequently, an extremely high degree of cross-reactivity is essential for effective T cell immunity. Ag recognition by T cells is unique in that it involves a coreceptor that binds at a site distinct from the TCR to facilitate productive engagement of the pMHC. In this study, we show that the CD8 coreceptor controls T cell cross-reactivity for pMHCI Ags, thereby ensuring that the peripheral T cell repertoire is optimally poised to negotiate the competing demands of responsiveness in the face of danger and quiescence in the presence of self.