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Association for Research in Vision and Ophthalmology, Investigative Ophthalmology & Visual Science, 11(52), p. 8278

DOI: 10.1167/iovs.11-8167

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Free Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Reduces Retinal Vascular Permeability in Association with a Reduction of Acid Sphingomyelinase (ASMase)

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Intravitreal administration of IGFBP-3NB preserves junctional integrity in the presence of VEGF or laser injury by reducing BRB permeability in part by modulating sphingomyelinase levels.