Published in
Public Library of Science, PLoS Computational Biology, 11(7), p. e1002223, 2011
DOI: 10.1371/journal.pcbi.1002223
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- Public Library of Science
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- ORCID
- [www.ncbi.nlm.nih.gov] | PDF
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- [hdl.handle.net] | PDF
- [doaj.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [helvia.uco.es] | PDF
- [publications.tno.nl] | PDF
Tools
Transcriptomic Coordination in the Human Metabolic Network Reveals Links between n-3 Fat Intake, Adipose Tissue Gene Expression and Metabolic Health
,
Ben-E.-N. van Ommen,
Hannelore Daniel,
Sinead Toomey,
Ingrid M. F. Gjelstad,
Isobel C. Gormley,
Pablo Pérez-Martinez,
Christian A. Drevon,
Jose López-Miranda ,
Helen M. Roche
Full text: Download
Abstract
Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to pathway analysis, we have developed a joint multivariate and network-based approach to analysis of a dataset of habitual dietary records, adipose tissue transcriptomics and comprehensive plasma marker profiles from human volunteers with the Metabolic Syndrome. With this approach we identified prominent co-expressed sub-networks in the global metabolic network, which showed correlated expression with habitual n-3 PUFA intake and urinary levels of the oxidative stress marker 8-iso-PGF(2α). These sub-networks illustrated inherent cross-talk between distinct metabolic pathways, such as between triglyceride metabolism and production of lipid signalling molecules. In a parallel promoter analysis, we identified several adipogenic transcription factors as potential transcriptional regulators associated with habitual n-3 PUFA intake. Our results illustrate advantages of network-based analysis, and generate novel hypotheses on the transcriptomic link between habitual n-3 PUFA intake, adipose tissue function and oxidative stress.