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Cell Press, Current Biology, 19(24), p. 2217-2227, 2014

DOI: 10.1016/j.cub.2014.08.006

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Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons.

Journal article published in 2014 by Ulrike Hüsken, Hl Stickney, Gaia Gestri, Ih Bianco, Ana Faro, Rm Young ORCID, Myriam Roussigne, Ta Hawkins, Ca Beretta, Irena Brinkmann, Alessio Paolini, Raquel Jacinto, Shahad Albadri, Elena Dreosti, Matina Tsalavouta and other authors.
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This paper is available in a repository.

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Abstract

Although left-right asymmetries are common features of nervous systems, their developmental bases are largely unknown. In the zebrafish epithalamus, dorsal habenular neurons adopt medial (dHbm) and lateral (dHbl) subnuclear character at very different frequencies on the left and right sides. The left-sided parapineal promotes the elaboration of dHbl character in the left habenula, albeit by an unknown mechanism. Likewise, the genetic pathways acting within habenular neurons to control their asymmetric differentiated character are unknown.