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SAGE Publications, Clinical Medicine Insights: Cardiology, (7), p. CMC.S8445, 2013

DOI: 10.4137/cmc.s8445

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Pleiotropic Effects of Antiarrhythmic Agents: Dronedarone in the Treatment of Atrial Fibrillation

Journal article published in 2013 by Jordi Heijman ORCID, Gerd Heusch, Dobromir Dobrev ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Atrial fibrillation remains the most common arrhythmia in clinical practice. Dronedarone is an antiarrhythmic drug for the maintenance of sinus rhythm in patients with atrial fibrillation. Dronedarone is an amiodarone derivative developed to reduce the number of extracardiovascular side effects. Dronedarone has undergone extensive experimental and clinical testing during the last decade. On the aggregate, these studies have highlighted a complex set of pleiotropic actions that may contribute to dronedarone's antiarrhythmic effects. In this review, we summarize the clinical studies that have evaluated dronedarone and provide an overview of dronedarone's electrophysiological and nonelectrophysiological pleiotropic actions.