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American Heart Association, Circulation Research, 11(108), p. 1378-1380, 2011

DOI: 10.1161/circresaha.110.234419

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Thematic Series on the Pathobiology of Vascular Calcification

Journal article published in 2011 by Dwight A. Towler ORCID, Linda L. Demer ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Vascular calcification increasingly afflicts our aging, dysmetabolic population. Once considered only a passive process of dead and dying cells, data from multiple laboratories worldwide have converged to demonstrate that vascular calcification is a highly regulated form of biomineralization. The goal of this thematic review series is to highlight what is known concerning the biological “players” and “game rules” with respect to vascular mineral metabolism. Armed with this understanding, it is hoped that novel therapeutic strategies can be crafted to prevent and treat vascular calcium accrual, to the benefit of our patients afflicted with arteriosclerotic valvular and vascular diseases.